Perioperative oxygen supplementation and surgical site infection.
The perioperative use of a high fraction of inspired oxygen (FiO2) is recommended by both the United States Centers for Disease Control and Prevention and the World Health Organization, but this practice is controversial. In a multicenter randomized trial (i-PROVE O2) comparing outcomes of over 700 patients who underwent abdominal surgery with FiO2 0.80 versus 0.30 intraoperatively and for three hours postoperatively, the rates of postoperative surgical site infection (SSI), atelectasis, and myocardial ischemia were similar in both groups [Br J Anaesth. 2020;124(1):110. Epub 2019 Nov 22]. Based on these and similar previous data, we do not target a high intraoperative FiO2 to prevent SSI.